Ley et al studied the impact of mutations in DNMT3A on survival in patients with acute myeloid leukemia (AML). These can help to identify a patient who may benefit from more aggressive or a more novel therapy. The authors are from Washington University in St. Louis.
DNMT3A encodes a DNA methyltransferase.
Location: 2p23
Mutations in DNMT3A may include:
(1) frameshift
(2) nonsense
(3) splice-site
(4) deletion
Parameters impacting survival:
(1) age in years
(2) presence of any DNMT3A mutation
Age in Years
DNMT3A Mutation
5-Year Survival
<= 60 years
absent
55%
<= 60 years
present
26%
> 60 years
absent
12%
> 60 years
present
0%
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