Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is a rare hematologic disorder that can be a challenge to diagnose. Immunostaining can distinguish it from other dermal infiltrating tumors.


Synonym: CD4+CD56+ hematodermic neoplasm


Immunostaining results that distinguish BPDCN from leukemia cutis (Cronin et al):

(1) myeloperoxidase negative

(2) CD4 positive

(3) CD56 positive

(4) CD123 positive

(5) T cell leukemia 1 (Tcl-1) positive


Additional stains that may be helpful:

(1) CD43 positive

(2) CXCL12 (positivity associated with leukemia and poor prognosis)


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