Overproduction of a monoclonal protein may be associated with underproduction of uninvolved immunoglobulins.

Immunoparesis is the suppression in the production of one or more uninvolved immunoglobulins associated with a monoclonal protein.


It may affect 1, 2 or more immunoglobulin isotypes.


It is a significant risk factor for progression to myeloma.


Number of Reduced Immunoglobulin Isotypes

Median Time to Progression


159 months


78 months


32 months


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