Cronin et al proposed an immunohistochemical algorithm for the diagnosis of myeloid leukemia cutis. The authors are from Stanford University.
Patient selection: CD3 negative, CD20 negative malignant infiltrate of the skin that is myeloperoxidase and/or CD43 positive
Immunohistochemical pattern for classification:
(1) myeloperoxidase (MPO)
(2) CD68
(3) CD56
(4) CD117
|
MPO |
CD68 |
CD56 |
CD117 |
Node |
|
positive |
NA |
NA |
NA |
A |
|
negative |
negative |
NA |
NA |
B |
|
negative |
positive |
positive |
NA |
C |
|
negative |
positive |
negative |
positive |
D |
|
negative |
positive |
negative |
negative |
E |
|
Node |
Diagnosis |
|
A |
myeloid leukemia cutis |
|
B |
other hematologic malignancy (CD30 positive lymphoproliferative disorder, blastic plasmacytoid dendritic cell neoplasm, other) |
|
C |
myeloid leukemia cutis or blastic plasmacytoid dendritic cell neoplasm |
|
D |
myeloid leukemia cutis or mast cell sarcoma |
|
E |
myeloid leukemia cutis |
Specialty: Hematology Oncology
ICD-10: ,
