A patient with tuberculosis and HIV disease may undergo the immune reconstitution inflammatory syndrome (IRIS) after highly active antiretroviral therapy (HAART) is started.
Clinical features of IRIS associated with tuberculosis:
(1) fever
(2) cough and/or dyspnea
(3) abdominal pain
(4) lymphadenopathy
(5) hepatosplenomegaly
(6) progression in radiologic changes in the chest X-ray
(7) onset of new symptoms or progression of central nervous system disease
Timing of antituberculous therapy and HAART is important for optimizing the patient's outcome.
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