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Immune Reconstitution Inflammatory Syndrome (IRIS)

Purpose:

To evaluate a patient for immune reconstitution syndrome (IRIS) following discontinuation of tumor necrosis factor alpha (TNF) blocking therapy.

Specialty:

Clinical Pharmacology & Toxicology

Objective:

drug interactions, response to therapy, adverse effects

ICD-10:

M30-M36, D89.82, E06.3, L63, D68.6, K75.4, K51, D69.3, L90.0, E27.1, E05.0, M45, K50, G35, G70, L10, L40, L88, M05, M06, G25.8, L80

Description:

Discontinuing an tumor necrosis factor alpha (TNF alpha) blocking agent reactivates the patient's immune system. If the patient has developed an infection then the reconstituted immune system can trigger a system inflammatory reaction termed the immune reconstitution inflammatory syndrome (IRIS).

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