Patient selection: malignancy OR status post hematopoietic stem cell transplant
General host factors:
(1) neutropenia (absolute neutrophil count < 500 per µL for > 10 days)
(2) persistent fever for > 96 hours refractory to appropriate broad-spectrum antibacterial treatment
(3) (body temperature > 38°C OR < 36°C) AND a predisposing condition (see table below)
(4) prolonged use (> 3 weeks) of corticosteroids in previous 60 days (2 months)
Host factors seen in hematopoietic stem cell transplants:
(1) evidence of graft-vs-host disease, especially when severe (>= grade 2) or chronic, extensive disease
Predisposing condition associated with abnormal body temperature:
(1) neutropenia > 10 days in previous 60 days (2 months)
(2) recent or current use of significant immunosuppressive agents in previous 30 days (1 month)
(3) proven or probable invasive fungal infection during a previous episode of neutropenia
(4) coexistence of symptomatic AIDS
