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Identifying Matrix Effect in Proficiency Test and Calibration Materials

Specialty:

Clinical Laboratory
Nephrology, Urology, Obstetrics & Gynecology, Pedatrics, Genetics
Cardiology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care

Objective:

ICD-10:

Description:

Matrix effect refers to the impact of an artificial sample on a test method or instrument unrelated to the measured analyte. This can cause significant problems when comparing the accuracy between different laboratories using the same material for proficiency testing. According to the NCCLS guidelines, if the cause of the problem can be identified then it is called an interference; if it cannot be identified, then it is termed a matrix effect.

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