A patient with sickle cell disease may show hypogonadism.
Causes of hypogonadism in a patient with sickle cell disease.
(1) reduced release of LH and FSH (hypogonadotropic)
(2) hydroxyurea
(3) testicular infarction (primary testicular failure)
(4) opioid therapy
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Serum Testosterone
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Serum LH
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Status (Ribeiro et al)
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>= 300 ng/dL
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<= 9.4 mIU/mL
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eugonadism
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< 300 ng/dL
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> 9.4 mIU/mL
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primary hypogonadism
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< 300 ng/dL
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<= 9.4 mIU/mL
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secondary hypogonadism
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>=300 ng/dL
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> 9.4 mIU/mL
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compensated hypogonadism
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Complications:
(1) delayed puberty
(2) reduced fertility
