Therapy with tramadol can result in hypoglycemia, which can be severe.

It can be seen with therapeutic doses or with overdose.


It can occur in both diabetics and non-diabetics,


Clinical features:

(1) Therapy with tramadol.

(2) Detection of hypoglycemia.

(3) Blood glucose normalizes after the tramadol is discontinued.

(4) other causes of hypoglycemia are excluded.

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