Gell and Coombs classified different types of hypersensitivity reactions.
Term |
Key Factor |
Type |
immediate |
IgE and mast cell degranulation |
I |
antibody-mediated |
IgM and IgG antibodies to fixed antigen, complement binding with cytolysis |
II |
immune complex |
circulating antigen which binds antibodies and complement, deposited in vessel walls with vasculitis |
III |
delayed, cell-mediated |
T-cells with cytokine release, natural killer cells |
IV |
Type |
Example |
I |
allergy |
II |
immune hemolysis |
III |
serum sickness |
IV |
reaction to PPD |
Purpose: To classify an immune response using the scheme of Gell and Coombs.
Specialty: Immunology/Rheumatology
Objective: clinical diagnosis, including family history for genetics
ICD-10: T78.4,