Minocycline may be given for a long period of time in patients with acne or other conditions. Some patients develop hyperpigmentation that can be disfiguring.
Cutaneous Location
Pigment
Type
blue-black pigmentation on the face at sites of inflammation or scarring
hemosiderin
Type 1
circumscribed blue-grey pigmentation on arms and legs in normal skin
hemosiderin and melanin
Type 2
diffuse muddy-brown color on sun-exposed skin
melanin
Type 3
blue-grey pigmentation over thorax within scar tissue
melanin with calcium
Type 4
Additional sites:
(1) nail beds
(2) subcutaneous fat
(3) sclera
(4) oral mucosa
(5) teeth
(6) sites of inflammation (leprosy, etc)
Conditions associated with increased risk:
(1) atopic dermatitis
(2) pemphigus
(3) pemphigoid
(4) steroid therapy
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