Therapy with a beta-blocker may be associated with hyperkalemia.
Occurrence: propranolol, non-cardio-selective beta-blockers, Nebivolol (a cardioselective vasodilatory beta-1 receptor blocker)
Clinical features:
(1) elevation of serum potassium concentration after starting a beta-blocker
(2) resolution of the hyperkalemia after discontinuing the beta-blocker
(3) absence of alternative explanations for the hyperkalemia
Possible mechanisms:
(1) polymorphism of cytochrome P450 CYP2D6
