A patient with thalassemia may develop a hypercoagulable state that may be overlooked in some patients.
Risk factors for hypercoagulability:
(1) thalassemia intermedia
(2) post-splenectomy thrombocytosis
(3) chronic activation of platelets
(4) decreased serum levels of antithrombin III, protein C and/or protein S
(5) antiphospholipid antibodies
(6) family history of thrombosis
(7) personal history of thrombosis
(8) older age (> 35 years)
(9) hemoglobin < 9 g/dL
(10) not being regularly transfused (transfusion independence)
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Specialty: Hematology Oncology, Clinical Laboratory
