A number of tumors may secrete aldosterone, resulting in clinical hyperaldosteronism. These tumors feature an elevated blood aldosterone concentration that normalizes if the tumor is completely resected.


The most common lesions associated with hyperaldosteronism are:

(1) unilateral or bilateral adrenal cortical adenomas

(2) adrenal hyperplasia


Tumors that can produce aldosterone include:

(1) primary or metastatic adrenocortical carcinoma

(2) adrenal adenoma in ectopic adrenal tissue

(3) ovarian tumors (arrhenoblastoma, lipid cell tumor, malignant sex cord stromal tumor, other)

(4) leiomyosarcoma

(5) possibly non-Hodgkin's lymphoma


A tumor that produces aldosterone may also produce other compounds including renin, cortisol and norepinephrine.


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