Situations where reported:
(1) following parathyroidectomy in a patient with hyperparathyroidism (most often secondary to renal disease)
(2) following therapy for thyrotoxicosis
Laboratory features:
(1) hypocalcemia
(2) serum phosphate <= 3.0 mg/dL
(3) serum magnesium often reduced
(4) iPTH 50 to 100 pg/mL (normal to slightly elevated; with hypoparathyroidism the iPTH is below the lower limit of the normal reference range)
(5) serum 1,25-dihydroxy vitamin D normal to increased
(6) low to absent calcium in urine (rules out hypercalcuria)
It usually appears within 1-2 days of treatment for the demineralizing condition.
The lowest levels of calcium is reached during the first week.
Most patients recover to normal within 3 weeks but some patients may not recover for several years.
