A patient with Type 1 diabetes may develop a "honeymoon period" soon after the diagnosis of diabetes is made, with a transient recovery in beta-cell function.


Patient selection: Type 1 diabetic with the need for insulin


Clinical features:

(1) Temporary return of beta-cell function with increased endogenous insulin release soon after the diagnosis of diabetes has been made.

(2) Temporary decrease in the need for exogenous insulin, with a risk for hypoglycemia if the exogenous dose is not decreased.

(3) After several weeks or months the endogenous production decreases, which is associated with the need for increasing the exogenous insulin dose.


The increase in endogenous insulin production can be confirmed by an increase in serum C-peptide levels.


It is recommended not to totally discontinue the exogenous insulin dose during the honeymoon period, since this may help preserve beta-cell function.


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