Cells similar to Sternberg-Reed cells can be seen in non-Hodgkin's lymphoma. These may be referred to as Hodgkin-like cells (cHL).


Features of non-Hodgkin lymphomas with Hodgkin-like cells:

(1) cells are positive for CD15 and/or CD30

(2) cells are negative for B cell markers (CD20. PAX5, etc)

(3) other features of Hodgkin's disease are absent

(4) presence of a B or T cell lymphoproliferative disorder

(5) exclusion of alternative explanations


Hodgkin-like cells:

(1) have nucleoli that tend to be small and multiple

(2) can occur in clusters or sheets

(3) may infiltrate sinusoids


Some cases with Hodgkin-like cells may be associated with Epstein-Barr virus (EBV).


Differential diagnosis:

(1) composite lymphoma (mixed Hodgkins and non-Hodgkins lymphoma)


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