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HLA-B*58:01 Genotype and Allopurinol-Induced Hypersensitivity Reaction (Severe Cutaneous Adverse Drug Reaction, SCAR, DRESS)

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care
Nephrology, Urology, Obstetrics & Gynecology, Pedatrics, Genetics

Objective:

ICD-10:

Description:

Allopurinol-induced hypersensitivity reactions (severe cutaneous adverse drug reactions, SCAR, Stevens-Johnson Syndrome, toxic epidermal necrolysis, DRESS, drug rash with eosinophilia and systemic symptoms) are potentially fatal reactions with multifactorial causation. One important risk factor for certain racial groups is the HLA-B genotype.

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