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Description

An HIV-positive patient may develop an inflammatory myofibroblastic tumor (IMT). The development in an IMT in a patient with AIDS is a poor prognostic sign.


Tissue source: mesenchymal

 

Behavior: low malignant potential with many cured by complete excision

 

Sites of occurrence:

(1) lung

(2) adrenal gland

(3) GI tract

(4) spinal cord

(5) head and neck

(6) other extrapulmonary sites

 

Histologic features:

(1) spindle cells proliferation without atypia

(2) abundant small blood vessels

(3) myxoid and collagenous matrix

(4) mixed inflammatory infiltrate

 

Positive immunoperoxidase stains: vimentin (strong), smooth muscle actin (weak, focal)

Negative immunoperoxidase stains: S-100

 

Signs associated with worse prognosis:

(1) ALK1 positive

(2) RET, ROS1, NTRK3 or PDGFRbeta mutations

(3) metastases


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