Francoise et al reported a prognostic score for HIV-positive patients with histoplasmosis. The authors are from Universite de Gayane and affiliated hospitals in French Guiana.
Patient selection: HIV-positive with histoplasmosis
Parameters:
(1) ECOG performance status
(2) mental status
(3) dyspnea
(4) interstitial lung pattern on chest X-ray
(5) serum CRP in mg/L
(6) hemoglobin in g/dL
(7) platelet count per microliter
Parameter
Finding
Points
ECOG performance status
0 to 2
0
3 or 4
2
mental status
normal
0
altered
3
dyspnea
no
0
yes
2
interstitial lung pattern
no
0
yes
1
serum CRP
< 75 mg/L
0
>= 75 mg/L
2
hemoglobin
>= 9 g/dl
0
< 9 g/dL
1
platelet count
>= 100,000 per µL
0
< 100,000 per µL
1
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 12
• A score >= 5 is associated with 30-day mortality with a sensitivity of 0.84 and specificity of 0.81. The negative predictive value was 0.97.
Performance:
• The area under the ROC curve is 0.88-0.93.
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