Grisaru et al developed a histopathologic score that can predict the disease free interval after radical surgery for a woman with Stage IA2, IB1 or IB2 cervical carcinoma. The authors are from the Toronto-Sunnybrook Regional Cancer Center.
Parameters for Risk Score 1:
(1) pelvic lymph nodes
(2) capillary-lymphatic space invasion (lymphatic spread)
(3) depth of invasion
(4) margin status
(5) tumor grade
Parameters for Risk Score 2:
(1) pelvic lymph nodes
(2) capillary-lymphatic space invasion (lymphatic spread)
(3) depth of invasion
NOTE: The description of a tumor as Stage IA2, IB1 or IB2 is based on the T status of the tumor. The presence of positive lymph nodes would automatically make the tumor at least Stage IIIB.
|
Parameter |
Finding |
Points |
|
pelvic lymph nodes |
negative |
0 |
|
|
positive |
1 |
|
capillary-lymphatic space involvement |
negative |
0 |
|
|
positive |
1 |
|
depth of invasion |
< 10 mm |
0 |
|
|
>= 10 mm |
1 |
|
margin status |
negative |
0 |
|
|
positive |
1 |
|
tumor grade |
Grade 1 |
0 |
|
|
Grade 2 or 3 |
1 |
risk score 1 =
= SUM(points for all 5 parameters)
risk score 2 =
= SUM(points for the first 3 parameters)
Interpretation:
• minimum scores: 0
• maximum for risk score 1: 5
• maximum for risk score 2: 3
• The higher the score, the lower probability for disease free survival.
|
Risk Score 1 |
Probability of 48 Month Disease Free Survival |
|
0 |
98% |
|
1 |
95% |
|
2 |
85% |
|
3 |
84% |
|
4 |
62% |
|
5 |
75% |
from Figure 1, page 1906
|
Risk Score 2 |
Probability of 48 Month Disease Free Survival |
|
0 |
95% |
|
1 |
86% |
|
2 |
82% |
|
3 |
63% |
from Figure 2, page 1907
Specialty: Hematology Oncology, Surgery, general, Obstetrics & Gynecology
ICD-10: ,
