Borley et al reported a histopathologic score to describe chronic inflammation in the ileum associated with Crohn's disease. The authors are from John Radcliffe Hospital in Oxford.
Parameters corrected for area examined:
(1) lymphoid aggregate score
(2) granuloma score
Additional parameters:
(3) depth of lymphoid aggregate penetration
(4) wall thickness score
(5) perineural chronic inflammation
(6) macrophage infiltration
|
Parameter Corrected for Area |
Finding |
Points |
|
lymphoid aggregate score |
<= 5th percentile |
0 |
|
|
6 to 25th percentile |
1 |
|
|
26th to 50th percentile |
2 |
|
|
51st to 75th percentile |
3 |
|
|
>= 76th percentile |
4 |
|
granuloma score |
<= 5th percentile |
0 |
|
|
6 to 25th percentile |
1 |
|
|
26th to 50th percentile |
2 |
|
|
51st to 75th percentile |
3 |
|
|
>= 76th percentile |
4 |
where;
• Since the data is not available, these will be presented in terms ranging from none to high in the implementation.
|
Parameter |
Finding |
Points |
|
depth of lymphoid aggregate penetration |
none |
0 |
|
|
mucosa |
1 |
|
|
submucosa |
2 |
|
|
muscularis propria |
3 |
|
|
serosa or extramural fat |
4 |
|
wall thickness score |
< 2 SD above mean of controls |
0 |
|
|
2 to 4 SD above mean of controls |
1 |
|
|
4 to 6 SD above means of controls |
2 |
|
|
6 to 8 SD above mean of controls |
3 |
|
|
> 8 SD above mean of controls |
4 |
|
perineural chronic inflammation |
none |
0 |
|
|
mild |
1 |
|
|
moderate |
2 |
|
|
severe |
3 |
|
macrophage infiltration |
none or occasional in mucosa |
0 |
|
|
mild to moderate, mainly mucosal |
1 |
|
|
moderate, confined to submucosa |
2 |
|
|
extensive, transmural |
3 |
total score =
= SUM(points for all 6 parameters)
Interpretation:
• minimum score: 0
• maximum score: 25
• The higher the score the more severe the chronic inflammation.
Specialty: Gastroenterology
