Certain histopathologic features may be found in a patient with autoimmune pancreatitis. These findings are not diagnostic but can be supportive for the diagnosis.
Factors affecting interpretation:
(1) duration of disease (fibrosis increases with chronic disease)
(2) corticosteroid or immunosuppressive therapy (reduce inflammation)
(1) diffuse lymphoplasmacytic inflammation, which may be mild to marked in intensity
(2) periductal inflammation
(3) perineural inflammation
(4) venulitis and obstructive phlebitis
(1) diffuse fibrosis
(2) acinar atrophy
(1) inflammatory pseudotumor (dense proliferation of spindle and chronic inflammatory with collagen)
(2) periductal granulomas without pathogens
(1) evidence of benign or malignant neoplasm
(2) organisms seen in periductal granulomas
(3) other cause that can explain the findings better (tumor at the ampulla with obstruction, etc.)
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