Histology Activity Index (HAI) of Knodell et al for Chronic Hepatitis

Points

Periportal/Bridging Necrosis

0

none

1

mild piecemeal necrosis

3

moderate piecemeal necrosis (< 50% of circumference of most portal tracts)

4

marked piecemeal necrosis

5

moderate piecemeal necrosis plus bridging necrosis

6

marked piecemeal necrosis plus bridging necrosis

10

multilobular necrosis

Points

Intralobular Degeneration and Focal Necrosis

0

none

1

mild (acidophilic bodies, ballooning degeneration, necrosis)

3

moderate

4

marked

Points

Portal Inflammation

0

none or minimal

1

mild

3

moderate

4

marked with dense packing in more than two thirds of portal area

Points

Fibrosis

0

no fibrosis (normal connective tissue)

1

fibrosis confined to enlarged/expanded portal tracts

3

bridging fibrosis

4

cirrhosis