Rath et al proposed a histologic score for evaluating colon biopsies for experimental rats with hemorrhagic colitis. The same score can be applied to patients with hemorrhagic colitis.
(1) mucosal inflammation
(2) epithelial alterations
(3) mucosal hemorrhage
(4) mucosal erosions
neutrophils in lamina propria
neutrophils among epithelial cells, with cryptitis
mild and focal
moderate and focal
diffuse and severe
• Epithelial alterations include loss of goblet cells, anisnucleosis (variation in nuclear size), mitotic activity and apoptosis.
total score =
= SUM(points for all 4 parameters)
• minimum score: 0 = normal mucosa
• maximum score: 12
• The higher the score the more severe the colitis.
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