Malignant soft tissue tumors can be graded based on histologic features. The grade is an important determinant of patient survival.
|
Parameter |
Finding |
Points |
|
degree of tumor differentiation |
close resemblance to normal adult tissue (well-differentiated) |
1 |
|
|
tumor type clearly recognizable |
2 |
|
|
tumor type uncertain (poorly or undifferentiated) |
3 |
|
tumor necrosis |
no tumor necrosis on any slide |
0 |
|
|
tumor necrosis < 50% |
1 |
|
|
tumor necrosis >= 50% |
2 |
|
mitotic count |
0-9 per 10 high powered fields |
1 |
|
|
10 - 19 per 10 high powered fields |
2 |
|
|
>= 20 per 10 high powered fields |
3 |
where:
• diameter of high powered microscopic field not stated
total score =
= (points for tumor differentiation) + (points for tumor necrosis) + (points for mitotic count)
Interpretation:
• minimum score 2
• maximum score 8
|
Score |
Histologic Grade |
|
2 or 3 |
Grade 1 |
|
4 or 5 |
Grade 2 |
|
6, 7 or 8 |
Grade 3 |
Specialty: Hematology Oncology, Surgery, general, Surgery, orthopedic
