Histologic Grading Scheme of Rindi et al for a Foregut Neuroendocrine Tumor

Description

Rindi et al graded the histologic features of foregut neuroendocrine tumors. This can help identify tumors that may behave more aggressively and which may benefit from more aggressive management. The authors are from multiple hospitals in Europe and North America who participated in the Frascati Consensus Conference in Rome.

Parameters:

(1) mitotic count per 10 high power (40x objective) field (field area 2 square mm, which corresponds to a circular field diameter of 1.6 mm; total area 20 square mm)

(2) Ki-67 index of nuclear staining

Histologic areas to evaluate:

(1) mitotic count: highest mitotic activity

(2) Ki-67 index: highest nuclear labeling (using MIB1 antibody)

Measurements:

(1) mitotic count: >= 40 microscopic fields (average 4 groups of 10 fields)

(2) Ki-67 index (percent of 2,000 tumor cells with nuclear staining)

Mitotic Rate (per 10 hpf)	Ki-67 index in Percent	Histologic Grade
< 2	< 3	G1
2 to 20	3 to 20	G2
> 20	> 20	G3

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Description

Specialty

ICD-10