Histologic Grading of a Labial Salivary Gland Biopsy in Patients with Sjogren's Syndrome

Purpose: To grade a salivary or lacrimal gland for the degree of lymphocytic infiltration in a patient with Sjogren's disease.

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Evaluation

Are you evaluating a salivary or lacrimal gland in a patient with possible Sjogren's syndrome?

Yes

Lymphocytic infiltrate in 4 square mm

Number of foci (lymphohistiocytic aggregates with >= 50 cells) in entire histologic section

Number of foci in a 4 square mm area

Are the foci completely confluent and filling the area?

Yes

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Histologic grade of lymphocytic infiltration (Chisholm and Mason)

Focus score of Waterhouse

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Clinical Diagnosis, Including Family History For Genetics
- Classification Tree of Vitali et al for Primary Sjogren's Syndrome
Imaging Studies
Laboratory Tests
Criteria For Diagnosis
Severity, Prognosis, Stage
Differential Diagnosis And Mimics, Red Flags
- Classification Tree of Vitali et al for Primary Sjogren's Syndrome
- Exclusion Conditions in Diagnosis of Sjogren's Syndrome

Monitoring

Disease Progression
- Sjogren's Syndrome Disease Damage Index (SSDDI)
- Sjogren's Syndrome Disease Activity Index (SSDAI)
Comorbid Conditions
- Secondary Sjogren's Syndrome Associated with Hepatitis C Virus (HCV)

Specialty

Immunology/Rheumatology

Objective

laboratory tests
severity
prognosis
stage

ICD-10

M35.0 - Sicca syndrome [Sjogren]

Info

Purpose: To grade a salivary or lacrimal gland for the degree of lymphocytic infiltration in a patient with Sjogren's disease.

Specialty: Immunology/Rheumatology

Objective: laboratory tests, severity, prognosis, stage

ICD-10: M35.0,

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