Hyams developed a histologic grading system for esthesioneuroblastomas.
Histologic features:
(1) lobular architecture
(2) mitotic activity
(3) nuclear pleomorphism
(4) rosettes
(5) necrosis
Grade
Lobular Archi-tecture
Mitotic Activity
Nuclear Pleo-morphism
Rosettes
Tumor Necrosis
1
present
none
variable
2
mild to moderate
3
prominent
occasional
4
marked
definite
Homer-Wright pseudorosettes may be found in Grades 1 or 2.
Flexner rosettes may be found in Grade 3
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Specialty: Hematology Oncology, Surgery, general, Otolaryngology
