Hyams developed a histologic grading system for esthesioneuroblastomas.
Histologic features:
(1) lobular architecture
(2) mitotic activity
(3) nuclear pleomorphism
(4) rosettes
(5) necrosis
Grade |
Lobular Archi-tecture |
Mitotic Activity |
Nuclear Pleo-morphism |
Rosettes |
Tumor Necrosis |
1 |
present |
none |
none |
variable |
none |
2 |
present |
mild to moderate |
mild to moderate |
variable |
none |
3 |
variable |
prominent |
prominent |
variable |
occasional |
4 |
variable |
marked |
marked |
none |
definite |
Homer-Wright pseudorosettes may be found in Grades 1 or 2.
Flexner rosettes may be found in Grade 3
Specialty: Hematology Oncology, Surgery, general, Otolaryngology