Burger and Vogel graded astrocytomas based on histologic features. The authors are from Duke University.
Parameters:
(1) hypercellularity
(2) nuclear pleomorphism
(3) tumor necrosis
(4) vascular proliferation
Hyper-cellularity
Nuclear Pleo-morphism
Tumor Necrosis
Vascular Proliferation
Grade
slight
none
astrocytoma
moderate
variable
anaplastic astrocytoma
moderate to marked
present
glioblastoma multiforme
where:
• Tumor necrosis is required for the diagnosis of glioblastoma.
• A glioblastoma may show pseudopallisading around the areas of necrosis.
To read more or access our algorithms and calculators, please log in or register.
Specialty: Hematology Oncology, Surgery, general, Neurology
