Tang et al used a grading scheme for hemangiopericytoma of bone based on histologic features. This can help separate malignant tumors from less aggressive lesions. The authors are from the University of California at Los Angeles.
Histologic features of hemangiopericytomas:
(1) sheets of spindly cells surrounding numerous capillaries
(2) monotonous round-to-oval nuclei
(3) indistinct cytoplasmic borders
(4) reticulin sheath surrounding each tumor cell seen on silver stain
Feature
Grade 1
Grade 2
Grade 3
cellularity
hypocellular
more cellular
numerous
cytoplasm
abundant
moderate
scant
nuclei
small, ovoid
moderate size, ovoid
enlarged
chromatin
indistinct
peppery
atypical
nucleoli
none prominent
small
atypical
mitotic activity
0 –1 in 10 HPF
2 – 4 in 10 HPF
> 4 in 10 HPF
"deer antler" vascular pattern
striking
prominent
less discernible
where:
• A high powered field (HPF) was 250 times magnification (10 ocular, 25 objective)
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