The severity of acute reflux disease in esophageal biopsies can be graded based on the histologic changes in the mucosa and the degree of inflammation.
(1) mucosal appearance
(3) other findings
elevation of papillae to > 30% of mucosal length; basal zone increase to > 15% of mucosal length
elevation of papillae to > 50% of mucosal length; basal zone increase to > 15% of mucosal length
elevation of papillae and/or increase in basal zone
moderate with neutrophilic exudate
necrotic and ulcerated
after Table 1, page 734, Rantanen (2001)
none or indefinite
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