The severity of acute reflux disease in esophageal biopsies can be graded based on the histologic changes in the mucosa and the degree of inflammation.
Histologic parameters:
(1) mucosal appearance
(2) inflammation
(3) other findings
|
Mucosa |
Inflammation |
Other |
Grade |
|
normal |
none |
none |
0 |
|
elevation of papillae to > 30% of mucosal length; basal zone increase to > 15% of mucosal length |
minimal |
none |
1 |
|
elevation of papillae to > 50% of mucosal length; basal zone increase to > 15% of mucosal length |
mild |
none |
2 |
|
elevation of papillae and/or increase in basal zone |
moderate with neutrophilic exudate |
none |
3 |
|
reparative changes |
severe |
granulation tissue |
4 |
|
necrotic and ulcerated |
severe |
mild fibrosis |
5 |
|
necrotic and ulcerated |
severe |
extensive fibrosis |
6 |
after Table 1, page 734, Rantanen (2001)
|
Grade |
Description |
|
0 |
none or indefinite |
|
1 |
minimal |
|
2 |
mild |
|
3 |
moderate |
|
4 |
severe |
|
5 |
very severe |
|
6 |
very severe |
Specialty: Gastroenterology
ICD-10: ,
