Description

The Splendore-Hoeppli phenomenon consists of a number of histologic findings. It tends to be seen with a Th2 immunologic response and an eosinophilic host response.


 

Features of the Splendore-Hoeppli phenomenon:

(1) eosinophilic material

(2) form a radiating, star-like asteroid or club-shaped body

(3) around some triggering material (fungal, bacterial, parasitic, foreign body, etc)

(4) strong autofluorescence

 

The eosinophilic material consists of combinations of:

(1) immunoglobulin

(2) fibrin

(3) complement

(4) basic protein from eosinophilic granules

(5) fibronectin and other proteins

 


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