Renal damage caused by malignant hypertension may show a number of histologic features.


Histologic features of malignant hypertensive nephropathy:

(1) arteriolar fibrinoid necrosis

(2) concentric ("onion-skin") myxoid/mucinous intimal thickening of interlobular arteries

(3) ischemic changes in the glomerulus (see below)

(4) arterial thrombosis with infarction

(5) variable hypertrophy and hypergranulation of the juxtaglomerular cells


Ischemic changes in the glomerulus include:

(1) wrinkling of the capillary wall

(2) fibrinoid necrosis with segmental crescent formation


To read more or access our algorithms and calculators, please log in or register.