Fabre et al developed histologic criteria for the diagnosis of focal nodular hyperplasia (FNH). This should be used in conjunction with imaging findings and clinical features. The authors are from Hopital Beaujon in Clichy, France.
Evaluation: liver biopsy of a hepatic nodule
Major pathologic features:
(1) fibrous bands
(2) abnormal blood vessels
(3) reactive bile ductules
(4) nodularity
Minor pathologic features:
(1) sinusoidal dilatation
(2) perisinusoidal fibrosis
Major Features
Minor Features
FNH
>= 3
NA
definite
2
>=1
possible
2
0
negative
0 or 1
NA
negative
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