Wu et al reported the HEV-LFs score for evaluating a patient with liver failure associated with hepatitis E viral hepatitis. The authors are from Zhejiang University, Jiangsu Vocational College of Medicine, Jiangnan University and affiliated hospitals in China.
Patient selection: liver failure associated with hepatitis E viral hepatitis
Parameters:
(1) serum cholinesterase (CHE) concentration in U/L
(2) INR
(3) serum urea in mmol/L
(4) platelet count in 10^9/L
Parameter
Points
serum cholinesterase
-6.67 * LN(CHE)
INR
1.94 * LN(INR)
serum urea
1.12 * LN(urea)
platelet count
-0.43 * LN(count)
HEV-LFs score =
= 50.61 +SUM(points for the parameters)
Hepatic Fibrosis
Score Range
F1
-11 to 2
F2
-6 to 3
F3
-3 to 11
Score Cut-Offs
Hepatic Fibrosis
< -2.24
F1
-1.19 to -2.24
F2
> -1.19
F3
Performance:
• The area under the ROC curves is 0.87 for F1 fibrosis, 0.90 for F2 fibrosis, and 0.92 for F3 fibrosis.
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