The Heterozygosity Index (H or Het) is a measure of the informativeness of a genetic marker for linkage analysis. It is the probability that a randomly selected individual from the general population under random mating is heterozygous at the locus. It is useful for codominant loci only.


For a marker to a locus with n alleles:


H =

= 1 – (((frequency of allele 1)^2) + ((frequency of allele 2)^2) + ….. + ((frequency of allele n)^2))


According to Bridge, the heterozygosity index equals the polymorphism information content (PIC) for X-linked loci where the maternal contribution can always be resolved.


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