Hereditary flat adenoma syndrome (HFAS) is a rare polyposis syndrome that shares many of the features of familial adenomatous polyposis (FAP).
The chromosomal abnormality is at 5q21-q22 which is the same for FAP.
Features of HFAS:
(1) autosomal dominant inheritance
(2) multiple colonic adenomas, mostly flat
(3) the number of adenomas is usually < 100
(4) tend to occur in the cecum and right colon (proximal)
(5) high risk for developing a colonic adenocarcinoma
(6) presence of upper GI tract lesions (fundic gland polyps, gastric adenomas, duodenal adenomas) with increased risk for adenocarcinoma
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Specialty: Gastroenterology
