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Hereditary Defects in the Interferon-gamma and Interleukin-12 Pathway (Hereditary Susceptibility to Mycobacteria and Intracellular Pathogens)

Specialty:

Immunology/Rheumatology

Objective:

ICD-10:

Description:

Interleukin-12 (IL-12) and interferon-gamma (IFN-gamma) pathway is involved in the activation of NK cells, macrophages and other host defenses. An inherited defect in a component of the interferon-gamma and interleukin-12 pathway may make a person more susceptible to certain infectious agents and to autoimmune disorders.

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