Mucocutaneous candidiasis may be a hereditary condition in some families. An inherited defect in interleukin-17 (IL-17) immunity may underly many of these cases.
Patient selection: familial mucocutaneous candidiasis
Hereditary conditions associated with impaired IL-17 immunity:
(1) autosomal dominant gain-of-function mutations of STAT1 (signal transducer and activator of transcript 1, at 2q32.2)
(2) autosomal recessive deficiency in interleukin-17 receptor A (IL-17RA)
(3) autosomal dominant deficiency interleukin-17F (IL-17F)
Differential diagnosis:
(1) anti-cytokine antibodies
(2) other causes of immunodeficiency
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Specialty: Immunology/Rheumatology, Infectious Diseases
ICD-10: ,
