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Hepatotoxicity Associated with Oral Terbinafine Hydrochloride

Specialty:

Gastroenterology
Clinical Pharmacology & Toxicology

Objective:

ICD-10:

Description:

Terbinafine hydrochloride (Lamisil) is an allylamine that inhibits squalene epoxidase, an enzyme involved in the synthesis of fungal cell walls. A patient receiving oral terbinafine hydrochloride for a dermatophyte infection is at risk for hepatotoxicity. The patient should be informed prior to initiating therapy and should be instructed to contact the clinician if adverse effects develop during therapy.

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