Hung et al identified risk factors for anemia in patients treated for viral hepatitis C. The authors are from Chang Gung University in Kaohsiung, Taiwan.
Antiviral therapy: interferon-alpha-2b plus ribavirin
Severe anemia was defined as a hemoglobin < 10 g/dL.
(1) age in years
(3) platelet count
(4) body weight
age in years
< 50 years
>= 50 years
>= 150,000 per µL
< 150,000 per µL
>= 65 kilograms
< 65 kilograms
total number of risk factors =
= SUM(points for all 5 parameters)
• minimum number of risk factors: 0
• maximum number of risk factors: 4
• The risk of anemia increases with the number of risk factors present.
The time of severe anemia was significantly correlated with a sustained virologic response (absence of viral RNA at 24 weeks post-treatment), especially in patients with HCV genotype 1.
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Purpose: To identify a patient who is at risk for developing severe anemia durng antiviral therapy for viral hepatitis C based on the study of Hung et al.
Specialty: Hematology Oncology, Clinical Laboratory, Pharmacology, clinical
Objective: risk factors, pharmacogenetics, comorbid conditions
ICD-10: D60, D61, B15, B16, B17, B19,