Hepatic Fibrosis | Evaluation Using PGA Index & Procollagen III Peptide (PIIIP)

Purpose: To use the PGA index and procollagen III peptide concentration to identify a patient with liver disease who has developed hepatic fibrosis and/or cirrhosis.

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Evaluation

Are you evaluating a patient with liver disease?

Yes

INR for the patient

Serum GGT

Upper limit of normal for the GGT

Serum apolipoprotein A1

Lower limit of normal for apoA1

Procollagen III peptide

U/mL

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

PGA index

Does the PGA index exceed the cutoff of 3?

Does the PIIIP exceed the cutoff of 0.7?

Positive predictive value for fibrosis or cirrhosis

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Clinical Diagnosis, Including Family History For Genetics
Laboratory Tests
- Discriminant Function Distinguishing Cirrhosis from Chronic Hepatitis
Criteria For Diagnosis
- Child-Pugh Score for Grading Hepatic Cirrhosis
- MELD-XI Score for Evaluating a Cirrhotic Patient Being Treated with Oral Anticoagulants
Severity, Prognosis, Stage
Complications

Monitoring

Disease Progression
- Discriminant Function Distinguishing Cirrhosis from Chronic Hepatitis
Comorbid Conditions
- Collateral Vessels in Portal Hypertension

Specialty

Gastroenterology

Objective

severity
prognosis
stage

ICD-10

K70.3 - Alcoholic cirrhosis of liver
K71.7 - Toxic liver disease with fibrosis and cirrhosis of liver
K74 - Fibrosis and cirrhosis of liver

Info

Purpose: To use the PGA index and procollagen III peptide concentration to identify a patient with liver disease who has developed hepatic fibrosis and/or cirrhosis.

Specialty: Gastroenterology

Objective: severity, prognosis, stage

ICD-10: K70.3, K71.7, K74,

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