A patient with Wilson's disease may present with a hemolytic anemia.

Features of the anemia:

(1) Coombs-negative hemolytic anemia.

(2) Hemolytic crises can occur, sometimes in conjunction with fulminant hepatic necrosis.



(1) free radicals

(2) ceramide and acid sphingomyelinase affecting red blood cell membranes


The diagnosis is often made after other features of Wilson's disease are identified.


Differential diagnosis:

(1) pancytopenia due to copper deficiency from excess chelation therapy

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