Patient selection: status post cesarean section
Parameters during the first 24 hours after surgery:
(1) white blood cell count
(2) absolute neutrophil count
(3) absolute neutrophil count
(4) NLR (neutrophil to lymphocyte ratio)
(5) PLR (platelet to lymphocyte ratio
|
Parameter
|
Infection
|
No Infection
|
|
WBC count
|
15.08 +/- 6.16 (x10^9)
|
13.27 +/- 4.23 (x10^9)
|
|
absolute neutrophil
|
12.64 +/- 5.56 (x10^9)
|
10.79 +/- 3.90 (x10^9))
|
|
absolute lymphocyte
|
1.38 +/- 0.59 (x10^9)
|
1.59 +/- 0.57 (x10^9)
|
|
NLR
|
11.14 +/- 9.60
|
7.76 +/- 4.32
|
|
PLR
|
176.52 +/- 106.34
|
149.90 +/- 69.85
|
All of the biomarkers show overlap in their ranges, limiting the discriminatory ability. An elevated value may be associated with infection, but a lower value may not rule it out.
The area under the ROC curve is 0.67.
One approach to use the information is to create cut-offs, above which the patient should be screened for infection. This would be one of several screens looking for infection.
|
Parameter
|
Screen for Infection
|
|
WBC count
|
> 15 (x10^9)
|
|
absolute neutrophil
|
> 13 (x10^9)
|
|
NLR
|
> 10
|
|
PLR
|
> 200
|
