Description

Some patients taking dopamine replacement therapy for Parkinson’s disease (PD) develop the hedonistic homeostatic dysregulation syndrome (dopamine dysregulation syndrome). The patient takes doses of dopamine in excess of that required to alleviate motor impairment (“binging”).


 

Critieria for the diagnosis:

(1) The patient has Parkinson’s disease that is responsive to dopamine therapy.

(2) The patient takes increasing doses of dopamine replacement therapy that exceed the dose needed to relieve motor impairment.

(3) There is evidence of pathologic use – hoarding, drug seeking behavior, unwillingness to reduce dopamine dose, etc

(4) Impaired functioning – behavioral (anger, violence), social (family difficulties, loss of friends), occupational (job loss)

(5) The patient shows a hypomanic, manic or cyclothymic affective syndrome in relation to dopamine replacement therapy.

(6) The patient develops signs of withdrawal if dopamine replacement dose is decreased, with dysphoria, depression, irritability and/or anxiety

(7) The condition has been present for >= 6 months.

 


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