The Harris Platelet Syndrome (formerly called asymptomatic constitutional macrothrombocytopenia) is relatively common in certain parts of the Indian subcontinent.


Inheritance: autosomal dominant


Clinical features:

(1) The patient is from northeastern India, Bangladesh, Bhutan and Nepal or a descendant.

(2) Asymptomatic.


Laboratory features:

(1) mild to severe thrombocytopenia

(2) giant platelets (macrothrombocytes)

(3) normal platelet aggregation studies

(4) normal red and white blood cells


Differential diagnosis:

(1) May-Hegglin syndrome

(2) heterozygous Bernard Soulier syndrome

(3) gray platelet syndrome


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