Hard gelatin capsules come in different sizes based on volume.
Capsule Size
Volume in mL
000
1.40
00
0.95
0
0.68-0.75
1
0.50-0.55
2
0.37-0.40
3
0.30
4
0.21-0.25
5
0.13-0.15
If graphed out this shows an exponential change in volume vs size.
Factors affecting the fill of a capsule:
(1) pressure applied
(2) amount of dead space
(3) residual moisture
If a drug powder has a certain density in grams per mL
volume of drug powder in mL =
= (weight of powder in grams) / (density)
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Specialty: Pharmacology, clinical
