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Half-Life of Carbon Monoxide and the Impact of Oxygen Therapy

Purpose:

To use the kinetics of carbon monoxide excretion to estimate blood levels at different times after intoxication.

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care

Objective:

response to therapy

ICD-10:

X47

Description:

Carboxyhemoglobin formed following exposure to carbon monoxide decreases at a rate affected by oxygen exposure. Hyperbaric oxygen therapy can reduce the half life of carboxyhemoglobin by over 90% as compared to breathing room air. Increasing oxygen exposure can significantly reduce the time to elimination with reduced morbidity and mortality.

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